This evening Engine 91 and multiple other nits were alerted to the 2900blk of Brookwood St for a house fire with reports of entrapment.  Harrisburg Chief 1 and Chief 32-2 arrived to find fire showing and 2 occupants trapped on the 2nd floor.  A neighbors ladder was deployed to initiate rescues.  Truck 32 arrived as the 1st due special service and deployed multiple ground ladders to assist with rescue efforts.  Engine 91 arrived shortly after as the 1st due engine and deployed an attack line.  The engine crew held the fire to the room of origin.  2 conscious occupants were rescued from the second floor.